23484.rar Review

: This identifies a "drugable" target that is distinct from the nitric oxide/cGMP pathway.

: Isolation of mesenteric arteries and thoracic aorta; use of Danish Myo tension systems to measure vessel contraction/relaxation. 23484.rar

: Evidence that oxidant-induced PKG Iα disulfide formation occurs in vivo during hypertension. : This identifies a "drugable" target that is

: Western immunoblotting to detect the redox state of PKG and phosphorylation levels. 4. Results 23484.rar

: Protein Kinase G Iα (PKG Iα) is usually activated by cGMP, but it can also be activated by "oxidative stress" (specifically the formation of a disulfide bond at Cys42).

: Targeting the Oxidative Activation of Protein Kinase G Iα: A Novel Therapeutic Approach for Hypertension.