: This class targets the fungal cell wall rather than the membrane. They inhibit the enzyme -(1,3)-D-glucan synthase. Effect : This blocks the synthesis of
: This blocks an early step in ergosterol biosynthesis, leading to a toxic buildup of squalene and depletion of ergosterol. Common Examples : Terbinafine. Antifungal Agents - StatPearls - NCBI Bookshelf - NIH antifungal agent
To combat fungal infections safely, medical science targets biological structures and pathways that are unique to fungi. Modern antifungal agents are primarily categorized into four major classes based on their specific mechanisms: : This class targets the fungal cell wall
: Azoles inhibit the cytochrome P450-dependent enzyme lanosterol causing cell lysis.
-(1,3)-D-glucan, a major polysaccharide responsible for maintaining the structural integrity of the cell wall, causing cell lysis.