Foreman is running his own clinical trial for a pediatric Huntington’s drug. He is struggling with the ethics of the trial when one of his young patients, Sophia, begins to decline.

By the end of the episode, Wilson realizes that while he needs space, he can't fully "emancipate" himself from House because their dysfunction is a core part of their friendship.

Wilson decides he needs to stop being House’s "enabler" and moves out of their shared arrangement to find his own apartment.

House is skeptical of her independence, believing no teenager can truly be an adult. He spends much of the episode trying to prove she is lying about her age or her lifestyle to justify her "adulthood."