Playing at the Johan Cruyff Arena, Ajax took an early lead through Mohammed Kudus. However, Napoli responded with a ruthless attacking display. Giacomo Raspadori scored twice, while Giovanni Di Lorenzo, Piotr Zielinski, Khvicha Kvaratskhelia, and Giovanni Simeone all found the net in a 6-1 victory . This remains Ajax's heaviest defeat in European competition.
Before October 2022, the two clubs hadn't met in a competitive match since 1970. When they finally did in Group A, Napoli produced a "total football" lesson that stunned the football world.
While their modern meetings are most famous, the clubs first crossed paths in the round of 16: First Leg: Napoli won 1-0 at home.