[s10e19] Mr. And Mrs. Stewie -

After a brutal physical confrontation between Stewie and Penelope (while Brian is trapped in a giant blender), Stewie ultimately decides he cannot kill his best friend. Penelope leaves Quahog, though she remains one of the few characters to match Stewie's intellectual and diabolical prowess. Key Details Director: Joe Vaux Writer: Gary Janetti Guest Star: Cate Blanchett provides the voice for Penelope.

Stewie meets a girl named Penelope at a park and quickly discovers she is his female soulmate—a fellow evil genius with a penchant for high-tech weaponry and global chaos. The two begin a whirlwind romance fueled by destruction, but their relationship is tested when Penelope demands that Stewie kill Brian to prove his loyalty. [S10E19] Mr. and Mrs. Stewie

Brian is sidelined early in the episode when he attempts to date a girl from a local college but is quickly rejected. He later becomes the target of Penelope's jealousy after she views him as a distraction to Stewie’s "work." After a brutal physical confrontation between Stewie and