: SGK1 often acts as an oncogene , promoting tumor cell proliferation, metastasis, and resistance to therapies (e.g., Akt inhibitors) in breast, colon, and prostate cancers.
: Research compounds like EMD638683 , GSK650394 , and SI113 are being studied for their potential to treat cancer, metabolic disorders, and fibrotic diseases. Serum and glucocorticoid-regulated kinase 1 - Frontiers
: SGK1 stimulates intestinal glucose absorption via SGLT1 and promotes cellular glucose uptake in various tissues.