If you have a homebrewed "New" 3DS system, you can get the game running by following these steps:
: The game will appear as a wrapped present on your 3DS home menu. The Binding of Isaac Rebirth 3DS (USA) CIA eSho...
It or install on original "Old" 3DS, 3DS XL, or 2DS consoles. 💾 How to Install the .CIA File If you have a homebrewed "New" 3DS system,