This guide focuses on the molecular mechanism of otoferlin-mediated vesicle docking and Ca 2+raised to the 2 plus power sensing in inner hair cells (IHCs). Role: Otoferlin acts as a key Ca 2+raised to the 2 plus power sensor for synaptic vesicle fusion in auditory IHCs.
The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane"). tm,cc,jp
The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane. This guide focuses on the molecular mechanism of